Recommendations for gonadotoxicity surveillance in male childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup Consort

Recommendations for gonadotoxicity surveillance in male childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup Consort
The International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) was developed to critically examine the evidence and harmonize existing long-term follow-up guidelines. The European Union-funded PanCareSurFup (PCSF) Consortium collaborated with IGHG to identify treatments associated with increased risk of impaired spermatogenesis, testosterone deficiency, and physical sexual dysfunction in male childhood, adolescent and young adult (CAYA) cancer survivors, and evaluate surveillance strategies.The aim of the recommendations is to enhance evidence-based care for male CAYA cancer survivors. This is a collection of systematic reviews. The senior author Dr. Dan Green is well known for cancer survivorship at St. Jude's.
Guideline representatives from the North American Children’s Oncology Group (COG), Dutch Childhood Oncology Group (DCOG), Scottish Intercollegiate Guidelines Network (SIGN), United Kingdom Children’s Cancer and Leukaemia Group (CCLG), PCSF Consortium, and other international paediatric oncology societies developed a working group of experts from nine countries.

The experts looked for areas of concordance and discordance across the COG, DCOG, SIGN, and CCLG guidelines. They devised clinical questions to address areas of discordance for surveillance of impaired spermatogenesis, testosterone deficiency, and physical limitations that lead to sexual dysfunction (subsequently described as physical sexual dysfunction) covering the following key issues: who needs surveillance; which surveillance modality should be used; how often and for how long surveillance should be performed; and when survivors should be referred.

The authors performed systematic searches in the medical literature for studies of CAYA survivors.
These are very extensive international harmonized guidelines for surveillance of male CAYA survivors and will be helpful resource for counselling and managing patients in long-term follow-up.

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