Quality of Life and Mood Predict Posttraumatic Stress Disorder After Hematopoietic Stem Cell Transplantation

Quality of Life and Mood Predict Posttraumatic Stress Disorder After Hematopoietic Stem Cell Transplantation



El-Jawahri, A (2016), Cancer, (Link to abstract)


Hematopoietic stem cell transplantation (HSCT) is a high-intensity treatment which is associated with an important risk of long-term morbidity and mortality. This study looked at 90 patients over 18 years undergoing allogeneic and autologous transplants. Various tools to measure quality of life (QOL) were used to assess for post-traumatic stress disorder (PTSD) symptoms at 6 months after transplant. QOL had returned to baseline in most patients at 6 months but 28.4% met criteria for PTSD and 43.3% for depression.  Changes of QOL and depression scores within hospitalization predicted PTSD and QOL impairment at 6 months. The authors suggest early intervention during the HSCT procedure to reduce the risk of ongoing QOL impact.


* In adults, a significant proportion of patients experience depression and reduced QOL during transplant and PTSD and depression post HSCT.