Consensus expert recommendations for identification and management of asparaginase hypersensitivity and silent inactivation

Consensus expert recommendations for identification and management of asparaginase hypersensitivity and silent inactivation

van der Sluis IM, (2016) Haematologica, (Link to abstract)


Asparaginase is an essential component in the treatment of childhood ALL. This article is a consensus of expert opinions on the role of serum asparaginase level assessment, indications for switching asparaginase preparation, and monitoring after change in asparaginase preparation.


* Routine asparaginase activity monitoring for ALL patients has been started in Sickkids recently, it is important to understand the rationale and clinical implications.