6349 hematopoietic stem cell transplantation (HSCT) donor-recipient pairs (from 1988 to 2006) were examined for clinical and demographic predictors of outcome. The findings were validated in a second cohort of 4690 donor-recipient pairs (years 2007 to 2011). The authors found older donor age to be associated with lower survival in both cohorts. For every 10-year increment in donor age, there was a 5.5% increase in the hazard ratio for overall mortality. Similarly, HLA-matching was correlated with survival. In contrast, sex, parity of donor, and CMV serostatus were not associated with survival. ABO match seemed to have a modest impact on survival.
* This report further strengthens the association between older age of HSCT donor and lower survival as earlier suggested (http://www.bloodjournal.org/content/98/7/2043). In contrast to other reports (http://www.ncbi.nlm.nih.gov/pubmed/19642176), this analysis did not find an association between sex of donors and outcome.