Effect of Transfusion of Red Blood Cells With Longer vs Shorter Storage Duration on Elevated Blood Lactate Levels in Children With Severe Anemia

Effect of Transfusion of Red Blood Cells With Longer vs Shorter Storage Duration on Elevated Blood Lactate Levels in Children With Severe Anemia
Aggrey Dhabangi (2015), JAMA (Link to abstract)

290 Children with severe anemia and lactic acidosis were analyzed in this study after receiving red blood cell transfusions. The authors found that RBC units with longer storage duration (25-35 days) were not inferior to RBC units stored for up to 10 days as measured either by resolution of lactic acidosis at 8 hours (primary outcome measure), or by secondary outcomes defined by improvement in clinical symptoms, normalization of vital signs, correction of laboratory abnormalities, and improvement in cerebral tissue oxygen saturation.


* Longer storage duration of red blood cells does not affect the outcome in children with severe anemia in terms of resolution of clinical and laboratory parameters.