International incidence of childhood cancer, 2001–10: a population-based registry study

International incidence of childhood cancer, 2001–10: a population-based registry study
Childhood cancer burden is unknown in many low- and middle-income countries. The International Agency for Research on Cancer (IARC) and the International Association of Cancer Registries (IACR) have coordinated a study to publish the International Incidence of Childhood Cancer, volume 3 (IICC-3), which will include ages 0-19 (rather than 0-14 in the two previous volumes reported in 1988 and 1998).
This paper provides an overview of the incidence of malignancies and non-malignant neoplasms of the CNS in 2001-2010 for children aged 0-19, based on data collected in 153 population-based cancer registries in 62 countries. They included only registries that met standard data quality criteria and that covered the entire decade 2001-2010.
There were 385,509 incident cases in children aged 0-19 years. The overall age-standardized incidence rate was 140.6 per million person-years in children 0-14 years, which has increased from 124.0 in the 1980s, and 155.8 for aged 0-19 years. The most common were leukemia, followed by CNS tumors, and lymphomas. In children aged 15-19 years, the most common were lymphomas and the group of epithelial tumors and melanoma. Incidence rates were slightly higher in boys than girls. Incidence varied significantly between and within regions and by cancer type, sex, age, and racial and ethnic group.
The reported rates are influenced by selecting only registries with quality-assured data for the entire decade of 2001-2010. Some large registries were excluded if they didn't cover the entire decade. The non-malignant tumors in the USA were only registered from 2004 onwards and were therefore excluded. Approximately 30 cancer registries dropped out of the study. Multi-ethnic populations in Europe and Canada could not be readily studied.
This epidemiological population-based registry study updates information on cancer incidence in children aged 0-14 and adds the first global overview of cancer incidence in young people aged 15-19 years. They report an increase in the incidence of neoplasms since the 1980s in children aged 0-14 years. This is a unique global source of childhood cancer incidence that can be used for research and to inform public health policy.