Donor-to-Recipient ABO Mismatch Does Not Impact Outcomes of Allogeneic Hematopoietic Cell Transplantation Regardless of Graft Source

Donor-to-Recipient ABO Mismatch Does Not Impact Outcomes of Allogeneic Hematopoietic Cell Transplantation Regardless of Graft Source
There is controversy and conflicting reports regarding the influence of ABO mismatch on outcomes of allogeneic stem cell transplants and how to integrate ABO mismatch in the considerations of donor selection. This large retrospective study from the University of Minnesota assesses the impact of ABO mismatch on outcomes of allogeneic transplants from various graft sources.
Transplant outcomes of 1502 patients who underwent SCT from various graft sources between 2000 and 2014 were analyzed.
ABO match status did not significantly influence the outcomes of either engraftment, acute or chronic GVHD or NRM, regardless of stem cell source.
These results suggest that ABO matching should not be a major factor in choosing a donor for allogeneic stem cell transplant.