Risk of Subsequent Neoplasms During the Fifth and Sixth Decades of Life in the Childhood Cancer Study Cohort

Risk of Subsequent Neoplasms During the Fifth and Sixth Decades of Life in the Childhood Cancer Study Cohort

Turcotte L (2015), Journal of Clinical Oncology (Link to abstract)


This is a paper from the Childhood Cancer Survivorship Study, which is a retrospective cohort with ongoing longitudinal observation.  This report focuses on 14,364 survivors diagnosed between 1970 and 1986 who were 40 years or older at last contact.  It reports the cumulative incidence of new subsequent neoplasms occurring after the age of 40 as 34.6 % with survivors being twice as likely as the general population to receive a diagnosis of subsequent malignant neoplasm after this age.  Survivors were at particular risk for breast, renal, thyroid and soft tissue sarcomas.  Female sex and therapeutic radiation were identified as risk factors.


* Make sure our survivors are aware that their increased risk of second cancer is truly lifelong.  Think strategically about screening options.