High Prevalence of Hereditary Cancer Syndromes in Adolescents and Young Adults with Colorectal Cancer

High Prevalence of Hereditary Cancer Syndromes in Adolescents and Young Adults with Colorectal Cancer

Mark M, 2015, Journal of Clinical Oncology (Link to abstract)


This retrospective cohort study from MD Anderson evaluated 193 patients with colorectal cancer who underwent genetic counselling over a 5 year period.  They identified 35 % of these patients to have an identifiable hereditary cancer syndrome.  Whilst patients with a cancer syndrome were more likely to present at earlier stages and have a family history of cancer, 19 % of the hereditary syndromes were found in individuals with no family history.


*Refer ALL adolescents with colorectal cancer for genetic counselling regardless of family history or phenotype!


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