ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy

Morfuace et al, 2015 Cancer Research                   

Link to abstract: http://www.ncbi.nlm.nih.gov/pubmed/26199091

ABC membrane transporters have been implicated in several tumors as conferring chemotherapy-resistance by expelling the drug from the cell. Group 3 medulloblastoma is known to be particularly difficult to treat with current therapy. This group showed that ABC group 2 transporters have increased expression in both human and mouse group 3 medulloblastoma cells and this expression decreased in vitro response to 11/12 chemotherapeutic agents.

*In a mouse model they showed that blockade of ABCG2 using Ko143 increased tumor susceptibility to topotecan and the combination of these two drugs produced the longest survival time (compared to each individually).