Cesaro S (2015), British Journal of Haematology (Link to abstract)
This retrospective study assesses the outcomes and risk factors of a second allogeneic haematopoietic stem cell transplant in patients with acquired SAA and subsequent graft failure. A total of 162 patients were analyzed, as reported to the registry of the European Society for Blood and Marrow Transplantation between 1998 and 2009. After a median follow-up of 3.5 years, the 5-year overall survival was 60.7%. The only factor significantly associated with a better outcome in multivariate analysis was a Karnofsky/Lansky score ≥80.
* A second allogeneic HSCT is a feasible rescue option for graft failure in SAA but the need for a second HSCT significantly reduces the overall survival from 80-90% to 60%.