Childhood and Adolescent nodular lymphocyte predominant Hodgkin lymphoma – A review of clinical outcome based on the histological variants

Shankar et al (2015) British Journal of Haematology

Link to abstract: http://onlinelibrary.wiley.com/doi/10.1111/bjh.12055/abstract

Retrospective data collection, with pathological review of 60 biopsies (CCLG, Euronet PHL-LP1, OK Children’s Cancer Study Group HD3) between 2001 and 2014.  Aim to evaluate treatment outcome in patients with histopathological variants of nodular lymphocyte predominant HL (nLPHL) after de-escalation of therapy.  Patients: 5-16 years (med: 14y.o.); 47 with typical (nLPHL), 13 with variant nLPHL. 14 were treated with excision alone; 46 treated with chemo (40 CVP, 16 other regimens). 

*Compared to nLPHL, variant nLPHL is associated with lower complete response rates (CCR: 46% vs 81%) p = 0.029.  There were trends seen which were not significant: Higher stage at diagnosis (stage III: 23% vs 6%) and increased risk of relapse (15% vs 4%).