Biomarkers for Diagnosis and Prognosis of Sinusoidal Obstruction Syndrome after Hematopoietic Cell Transplantation

Akil A et al (2015) Biology of Blood and Marrow Transplantation                                                              

Link to abstract: http://www.ncbi.nlm.nih.gov/pubmed/26172478

In this study, candidate protein biomarkers of SOS (VOD) were identified using a quantitative mass spectrometry–based proteomics approach by comparing plasma pooled from 20 patients with and 20 patients without SOS. Six proteins were selected and then evaluated for diagnostic potential on samples from 80 patients with five more proteins, which were selected from the literature.

*The results identified a suggestive biomarker panel for diagnosis of SOS measured as early as on the day of transplant showing >80% correct prediction of SOS onset.