Hypoxia-reperfusion affects osteogenic lineage and promotes sickle cell bone disease

Hypoxia-reperfusion affects osteogenic lineage and promotes sickle cell bone disease

Dalle Carbonare L, 2015, Blood (Link to abstract)                                                          

Using a SCD mouse model, the authors showed that these mice [JB1] have reduced osteoblasts while osteoclasts were increased compared to healthy mice. Simulating vaso-occlusive crises with hypoxia-reperfusion events, osteoclast recruitement was seen and osteoblast activity was reduced. Zolendronic acid, a bisphosphonate, reduced bone loss in SCD mice with hypoxia-reperfusion damage.


* This study on SCD mice supports further evaluation of bisphosphonates in SCD patients to reduce sickle cell bone disease.