Free hemoglobin increases von Willebrand factor–mediated platelet adhesion in vitro: implications for circulatory devices

Free hemoglobin increases von Willebrand factor–mediated platelet adhesion in vitro: implications for circulatory devices

Da Q, 2015, Blood (Link to abstract)   


Patients on extra-corporeal life support (ECMO) are prone to hemolysis. This report analyzed the effect of free hemoglobin on thrombus formation in vitro. The authors found that free hemoglobin ≥50mg/dl induces thrombus-formation through GPIbα-vWF interaction. GPIbαantibodies inhibited platelet deposition.  Heparin insufficiently inhibited thrombus formation in this setting.


* Hemolysis and resulting free hemoglobin ≥50mg/dl are involved in thrombus formation in an ECMO model through GPIbα-vWF interaction. Inhibition of this process might decrease thrombus formation.