IL-1β, in contrast to TNFα, is pivotal in blood-induced cartilage damage and is a potential target for therapy

IL-1β, in contrast to TNFα, is pivotal in blood-induced cartilage damage and is a potential target for therapy

Van Vulpen LFD, (2015), Blood (Link to Abstract)                                                          


Joint bleeds from various causes can induce cartilage remodeling and apoptosis after a single event. In this article, the authors used in vitro analyses to study the effect of cytokine inhibition on cartilage damage. Postmortem human cartilage was extracted and cells were cultured. IL-1β inhibition within 24hrs from blood exposure led to dose-dependent recovery of cartilage dysfunction markers. TNFα inhibition did not show the same effect.


*IL-1β inhibition might be a target for prevention of blood-induced cartilage damage in joint bleeds.