Red blood cell transfusion is associated with increased hemolysis and an acute phase response in a subset of critically ill children

L’Acqua C (2015) American Journal of Hematology

Link to abstract: http://www.ncbi.nlm.nih.gov/pubmed/26183122

In this prospective study of critically ill children, the effect of RBC storage duration on extent of hemolysis was examined by comparing laboratory measurements obtained before, and 4 hours after RBC transfusions in 100 patients. They identified a subset of 21 patients with considerable extra-vascular hemolysis accompanied by an acute phase response. Storage duration of the RBC did not correlate with hemolysis and inflammation indicators, suggesting that other recipient and donor factors are more important in the induction of post transfusion hemolysis.