Efficacy of transfusion with granulocytes from G-CSF/dexamethasone–treated donors in neutropenic patients with infection

Price TH (2015), Blood (Link to abstract)                                                              

Granulocyte transfusion therapy has been used for 20 years without demonstrating clear efficacy in treating infections in neutropenic patients. This report from a multicenter randomized controlled trial included patients with neutropenia and proven/probable/presumed infection. Subjects were randomized to receive either standard antimicrobial therapy (n=56) or standard antimicrobial therapy plus daily granulocyte transfusions from donors stimulated with granulocyte colony-stimulating factor (G-CSF) and dexamethasone (n=58). The primary end point was a composite of survival plus response to antimicrobials, at 42 days after randomization. Transfused subjects received a median of 5 transfusions. Overall success rates were 42% and 43% for the granulocyte and control groups, respectively (P > .99), and 49% and 41%, respectively, for subjects who received their assigned treatments (P = .64). Success rates for granulocyte and control arms did not differ within any infection

* There is no evidence for superiority of giving granulocyte transfusions in addition to standard care with antimicrobials in subjects with neutropenia and infection.